| Product Name | Anti-Phospho-TAB2 (Ser450) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser450 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TAB2 |
|---|---|
| Gene Synonyms | CHTD2 TAB-2 MAP3K7IP2 |
| Gene Full Name | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 |
| Gene Summary | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| Alternative Names | CHTD2 FLJ21885 KIAA0733 MAP3K7IP2 Mitogen activated protein kinase kinase kinase 7 interacting protein 2 Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 OTTHUMP00000040125 TAB 2 TAB-2 Tab2 TAB2_HUMAN TAK1 binding protein 2 TAK1-binding protein 2 TGF beta activated kinase 1/MAP3K7 binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1-binding protein 2 |
| Molecular Weight(MW) | 76 kDa |
| Cellular Localization | Cytoplasm,Endosome,Lysosome,Membrane. |
| SwissProt ID | Q9NYJ8 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
