| Gene Symbol |
VCP
|
| Gene Synonyms |
p97 TERA CDC48 FTDALS6 |
| Gene Full Name |
valosin containing protein |
| Gene Summary |
This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017] |
| Alternative Names |
15S Mg(2+) ATPase p97 subunit 15S Mg(2+)-ATPase p97 subunit ALS14 ATPase p97 CDC48 IBMPFD MGC131997 MGC148092 MGC8560 p97 TER ATPase TERA TERA_HUMAN Transitional endoplasmic reticulum ATPase Valosin containing protein Valosin-containing protein VCP Yeast Cdc48p homolog |
| Molecular Weight(MW) |
89 kDa |
| Cellular Localization |
Cytoplasm, Endoplasmic reticulum, Nucleus. |