| Product Name | Anti-Phospho-5 Lipoxygenase (Ser523) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser523 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ALOX5 |
|---|---|
| Gene Synonyms | 5-LO 5LPG LOG5 5-LOX |
| Gene Full Name | arachidonate 5-lipoxygenase |
| Gene Summary | This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| Alternative Names | 5 LO 5 LOX 5-lipoxygenase 5-LO 5-LOX 5LOX 5LPG ALOX 5 Alox5 Arachidonate 5 lipoxygenase Arachidonate 5-lipoxygenase arachidonic 5-lipoxygenase alpha-10 isoform arachidonic 5-lipoxygenase delta-10-13 isoform arachidonic 5-lipoxygenase delta-13 isoform arachidonic 5-lipoxygenase delta-p10 isoform Arachidonic acid 5 lipoxygenase Leukotriene A4 synthase LOG 5 LOG5 LOX5_HUMAN MGC163204 |
| Molecular Weight(MW) | 78 kDa |
| Cellular Localization | Cytoplasm, Membrane, Nucleus. |
| SwissProt ID | P09917 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
