| Product Name | Anti-Phospho-MLKL (Thr349) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Thr349 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MLKL |
|---|---|
| Gene Synonyms | hMLKL |
| Gene Full Name | mixed lineage kinase domain like pseudokinase |
| Gene Summary | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
| Alternative Names | 9130019I15Rik FLJ34389 hMLKL Mixed lineage kinase domain like Mixed lineage kinase domain like protein Mixed lineage kinase domain like pseudokinase Mixed lineage kinase domain-like protein Mlkl MLKL_HUMAN |
| Molecular Weight(MW) | 54 kDa |
| Cellular Localization | Cell membrane, Cytoplasm, Membrane, Nucleus. |
| SwissProt ID | Q8NB16 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
