| Product Name | Anti-Phospho-p130 Cas (Tyr165) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Tyr165 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BCAR1 |
|---|---|
| Gene Synonyms | CAS CAS1 CASS1 CRKAS P130Cas |
| Gene Full Name | BCAR1 scaffold protein, Cas family member |
| Gene Summary | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] |
| Alternative Names | BCAR 1 Bcar1 BCAR1_HUMAN Breast cancer anti estrogen resistance 1 Breast cancer anti estrogen resistance 1 protein Breast cancer anti-estrogen resistance protein 1 CAS Cas scaffolding protein family member 1 CAS1 Cass1 Crk associated substrate Crk associated substrate p130Cas CRK-associated substrate CRKAS FLJ12176 FLJ45059 p130cas |
| Molecular Weight(MW) | 93 kDa |
| Cellular Localization | Cell junction, Cell projection, Cytoplasm. |
| SwissProt ID | P56945 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
