| Product Name | Anti-Phospho-53BP1 (Ser1618) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Ser1618 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TP53BP1 |
|---|---|
| Gene Synonyms | p202 53BP1 TDRD30 p53BP1 |
| Gene Full Name | tumor protein p53 binding protein 1 |
| Gene Summary | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
| Alternative Names | 53 BP1 53BP1 FLJ41424 MGC138366 p202 p53 binding protein 1 p53 BP1 p53-binding protein 1 p53BP1 TP53 BP1 TP53B_HUMAN Tp53bp1 TRP53 BP1 Tumor protein 53 binding protein 1 Tumor protein p53 binding protein 1 Tumor suppressor p53 binding protein 1 Tumor suppressor p53-binding protein 1 |
| Molecular Weight(MW) | 214 kDa |
| Cellular Localization | Centromere, Chromosome, Kinetochore, Nucleus. |
| SwissProt ID | Q12888 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
