| Product Name | Anti-Phospho-PAK1 /PAK2 (Thr423/Thr402) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Thr423/Thr402 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PAK1/PAK2 |
|---|---|
| Gene Synonyms | IDDMSSD p65-PAK PAKalpha alpha-PAK KNO2 PAK65 PAKgamma |
| Gene Full Name | p21 (RAC1) activated kinase 1/p21 (RAC1) activated kinase 2 |
| Gene Summary | This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]/The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008] |
| Alternative Names | ADRB2 Alpha PAK Alpha-PAK MGC130000 MGC130001 p21 activated kinase 1 p21 protein (Cdc42/Rac) activated kinase 1 p21-activated kinase 1 p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) p65 PAK p65-PAK P68-PAK PAK alpha PAK-1 Pak1 PAK1_HUMAN Paka PAKalpha Protein kinase MUK2 Rac/p21-activated kinase Serine/threonine-protein kinase PAK 1 STE20 homolog yeast C-t-PAK2 CB422 EC 2.7.11.1 Gamma PAK Gamma-PAK hPAK65 Kinase p21 (CDKN1A) activated kinase 2 p21 (CDKN1A)-activated kinase 2a p21 activated kinase 2 p21 protein (Cdc42/Rac)-activated kinase 2 p21 protein Cdc42 Rac activated kinase 2 p21-activated kinase 2 p21-activated kinase 65-KD p21-activated protein kinase I p21CDKN1A activated kinase 2 p27 p34 p58 p65PAK PAK 2 PAK-2 PAK-2p34 Pak2 PAK2_HUMAN PAK65 PAKgamma S6 H4 kinase S6/H4 kinase Serine threonine protein kinase PAK 2 Serine/threonine protein kinase PAK 2 |
| Molecular Weight(MW) | 61 kDa/58 kDa |
| Cellular Localization | Cell junction, Cell membrane, Cell projection, Chromosome, Cytoplasm, Cytoskeleton, Membrane, Nucleus. |
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
