| Product Name | Anti-Phospho-Flt3 / CD135 (Tyr842) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH |
| Modification | p-Tyr842 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FLT3 |
|---|---|
| Gene Synonyms | FLK2 STK1 CD135 FLK-2 |
| Gene Full Name | fms related receptor tyrosine kinase 3 |
| Gene Summary | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] |
| Alternative Names | CD 135 CD135 CD135 antigen Fetal liver kinase 2 FL cytokine receptor Flk 2 Flk2 Flt 3 FLT-3 Flt3 FLT3_HUMAN FMS like tyrosine kinase 3 Fms related tyrosine kinase 3 Fms-like tyrosine kinase 3 Growth factor receptor tyrosine kinase type III Ly-72 OTTHUMP0000004234 Receptor type tyrosine protein kinase FLT3 Stem cell tyrosine kinase 1 Stk 1 STK-1 Stk1 Tyrosine protein kinase receptor FLT3 Tyrosine-protein kinase receptor FLT3 |
| Molecular Weight(MW) | 113 kDa |
| Cellular Localization | Membrane, Endoplasmic reticulum lumen. |
| SwissProt ID | P36888 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
