| Product Name | Anti-Phospho-PAR4 (Thr163) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Thr163 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PAWR |
|---|---|
| Gene Synonyms | PAR4 Par-4 |
| Gene Full Name | pro-apoptotic WT1 regulator |
| Gene Summary | This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017] |
| Alternative Names | 2310001G03Rik PAR 4 PAR-4 Pawr PAWR_HUMAN PRKC Apoptosis WT1 Regulator PRKC apoptosis WT1 regulator protein Prostate apoptosis response 4 protein Prostate apoptosis response protein 4 prostate apoptosis response protein PAR-4 Transcriptional repressor Par-4-like protein PAWR Transcriptional repressor PAR4 WT1 Interacting Protein |
| Molecular Weight(MW) | 37 kDa |
| Cellular Localization | Cytoplasm,Nucleus. |
| SwissProt ID | Q96RI0 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
