| Product Name | Anti-Phospho-NEDD4L (Ser342) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser342 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NEDD4L |
|---|---|
| Gene Synonyms | RSP5 PVNH7 NEDD4-2 NEDD4.2 hNEDD4-2 |
| Gene Full Name | NEDD4 like E3 ubiquitin protein ligase |
| Gene Summary | This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
| Alternative Names | E3 ubiquitin protein ligase NEDD4 like protein E3 ubiquitin-protein ligase NEDD4-like KIAA0439 NED4L_HUMAN NEDD4 2 NEDD4 2c Nedd4-2 NEDD4-2a NEDD4.2 NEDD4b NEDD4L NEDD4La NEDD4Lb NEDD4Lc NEDD4Ld NEDD4Le NEDD4Lf NEDD4Lg NEDD4Lh NEDL3 Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase Neural precursor cell expressed developmentally down regulated 4 like RSP5 Ubiquitin protein ligase Rsp5 |
| Molecular Weight(MW) | 112 kDa |
| Cellular Localization | Cytoplasm,Endosome,Golgi apparatus. |
| SwissProt ID | Q96PU5 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
