| Product Name | Anti-Phospho-ALK (Tyr1096) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr1096 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ALK |
|---|---|
| Gene Synonyms | ALK1 CD246 NBLST3 |
| Gene Full Name | ALK receptor tyrosine kinase |
| Gene Summary | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] |
| Alternative Names | Alk ALK tyrosine kinase receptor ALK/EML4 fusion gene included ALK/NPM1 fusion gene included ALK_HUMAN anaplastic lymphoma kinase (Ki-1) Anaplastic lymphoma kinase Anaplastic lymphoma kinase Ki1 anaplastic lymphoma receptor tyrosine kinase CD 246 CD246 CD246 antigen EC 2.7.10.1 Ki 1 Ki1 mutant anaplastic lymphoma kinase NBLST 3 NBLST3 Tcrz TFG/ALK |
| Molecular Weight(MW) | 176 kDa |
| Cellular Localization | Cell membrane,Membrane. |
| SwissProt ID | Q9UM73 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
