| Gene Symbol |
HNF1A
|
| Gene Synonyms |
HNF1 LFB1 TCF1 MODY3 TCF-1 HNF-1A IDDM20 HNF1alpha HNF-1-alpha |
| Gene Full Name |
HNF1 homeobox A |
| Gene Summary |
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
| Alternative Names |
Albumin proximal factor Hepatic nuclear factor 1 alpha Hepatic nuclear factor 1 Hepatic transcription factor 1 alpha Hepatic transcription factor 1 Hepatocyte nuclear factor 1-alpha HNF 1 HNF 1A HNF-1-alpha HNF-1A hnf1a HNF1A_HUMAN Interferon production regulator factor LF B1 LF B1 hepatic nuclear factor LFB 1 LFB1 LFB1 hepatic nuclear factor Liver specific transcription factor LF B1 Liver specific transcription factor LFB1 Liver-specific transcription factor LF-B1 Maturity onset diabetes of the young 3 MODY 3 MODY3 TCF 1 TCF-1 TCF1 Transcription factor 1 Transcription factor 1 hepatic |
| Molecular Weight(MW) |
67 kDa |
| Cellular Localization |
Nucleus. |