| Product Name | Anti-Phospho-TERT (Ser824) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser824 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TERT |
|---|---|
| Gene Synonyms | TP2 TRT CMM9 EST2 TCS1 hTRT DKCA2 DKCB4 hEST2 PFBMFT1 |
| Gene Full Name | telomerase reverse transcriptase |
| Gene Summary | Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] |
| Alternative Names | CMM9 DKCA2 DKCB4 EST2 HEST2 htert hTRT PFBMFT1 TCS1 Telomerase associated protein 2 Telomerase catalytic subunit Telomerase reverse transcriptase Telomerase-associated protein 2 Telomere Reverse Transcriptase TERT TERT_HUMAN TP2 TRT |
| Molecular Weight(MW) | 127 kDa |
| Cellular Localization | Chromosome,Cytoplasm,Nucleus,Telomere. |
| SwissProt ID | O14746 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
