| Product Name | Anti-Phospho-FKBP4 (Tyr220) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Tyr220 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FKBP4 |
|---|---|
| Gene Synonyms | HBI p52 Hsp56 FKBP51 FKBP52 FKBP59 PPIase |
| Gene Full Name | FKBP prolyl isomerase 4 |
| Gene Summary | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] |
| Alternative Names | 51 kDa FK506-binding protein 52 kDa FK506 binding protein 52 kDa FK506-binding protein 52 kDa FKBP 59 kDa immunophilin FK506 binding protein 4 FK506-binding protein 4 FKBP 4 FKBP 52 FKBP 59 FKBP-4 FKBP-52 FKBP4 FKBP4_HUMAN FKBP51 FKBP52 protein FKBP59 HBI Hsp 56 HSP binding immunophilin HSP-binding immunophilin Hsp56 Immunophilin FKBP52 N-terminally processed p52 p59 p59 protein Peptidyl prolyl cis trans isomerase Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidylprolyl cis trans isomerase PPIase PPIase FKBP4 Rotamase T cell FK506 binding protein 59kD |
| Molecular Weight(MW) | 52 kDa |
| Cellular Localization | Cell projection,Cytoplasm,Cytoskeleton,Microtubule,Mitochondrion,Nucleus. |
| SwissProt ID | Q02790 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
