| Product Name | Anti-Phospho-AS160 (Ser341) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser341 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TBC1D4 |
|---|---|
| Gene Synonyms | AS160 NIDDM5 |
| Gene Full Name | TBC1 domain family member 4 |
| Gene Summary | This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| Alternative Names | Acrg embryonic lethality (mouse) minimal region ortholog Acrg embryonic lethality minimal region ortholog Acrg embryonic lethality mouse minimal region ortholog Akt substrate of 160 kDa AS 160 AS160 BUB2 CDC16 KIAA0603 NIDDM5 TBC (Tre 2 BUB2 CDC16) domain containing protein TBC Tre 2 BUB2 CDC16 domain containing protein TBC1 D4 TBC1 domain family member 4 Tbc1d4 TBCD4_HUMAN Tre-2 |
| Molecular Weight(MW) | 147 kDa |
| Cellular Localization | Cytoplasm. |
| SwissProt ID | O60343 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
