| Gene Symbol |
IGF1R
|
| Gene Synonyms |
IGFR CD221 IGFIR JTK13 |
| Gene Full Name |
insulin like growth factor 1 receptor |
| Gene Summary |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
| Alternative Names |
CD221 CD221 antigen IGF 1 receptor IGF 1R IGF I receptor IGF-I receptor Igf1r IGF1R_HUMAN IGFIR IGFIRC IGFR Insulin like growth factor 1 receptor Insulin like growth factor 1 receptor precursor Insulin-like growth factor 1 receptor beta chain Insulin-like growth factor I receptor JTK13 MGC142170 MGC142172 MGC18216 Soluble IGF1R variant 1 Soluble IGF1R variant 2 |
| Molecular Weight(MW) |
155 kDa |
| Cellular Localization |
Cell membrane,Membrane. |