| Gene Symbol |
POLR2A
|
| Gene Synonyms |
RPB1 RPO2 POLR2 POLRA RPBh1 RPOL2 NEDHIB RpIILS hsRPB1 hRPB220 |
| Gene Full Name |
RNA polymerase II subunit A |
| Gene Summary |
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008] |
| Alternative Names |
DNA directed RNA polymerase II subunit RPB1 hRPB220 hsRPB1 POLR2 POLR2A POLRA polymerase (RNA) II (DNA directed) polypeptide A 220kDa RNA polymerase II subunit 1 RNA polymerase II subunit B1 RP02 RPB220 RPBh1 RpIILS RPO21 RPOL2 SUA8 |
| Molecular Weight(MW) |
217 kDa |
| Cellular Localization |
Chromosome,Cytoplasm,DNA-directed RNA polymerase,Nucleus. |