| Product Name | Anti-Phospho-LRP6 (Ser1420) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser1420 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LRP6 |
|---|---|
| Gene Synonyms | EVR8 OPTA4 ADCAD2 STHAG7 |
| Gene Full Name | LDL receptor related protein 6 |
| Gene Summary | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009] |
| Alternative Names | ADCAD2 C030016K15Rik Cd FLJ90062 FLJ90421 LDL receptor related protein 6 Low density lipoprotein receptor related protein 6 Low-density lipoprotein receptor-related protein 6 LRP-6 LRP6 LRP6_HUMAN OTTHUMP00000238979 OTTHUMP00000238980 OTTHUMP00000238982 STHAG7 |
| Molecular Weight(MW) | 180 kDa |
| Cellular Localization | Cell membrane, Endoplasmic reticulum, Membrane. |
| SwissProt ID | O75581 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
