| Product Name | Anti-Phospho-PKA-R2 beta (Ser114) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser114 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PRKAR2B |
|---|---|
| Gene Synonyms | PRKAR2 RII-BETA |
| Gene Full Name | protein kinase cAMP-dependent type II regulatory subunit beta |
| Gene Summary | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008] |
| Alternative Names | AI451071 AW061005 cAMP dependent protein kinase type II beta regulatory chain cAMP dependent protein kinase type II beta regulatory subunit cAMP-dependent protein kinase type II-beta regulatory subunit H RG363E19.2 KAP3_HUMAN MGC116401 Pkarb2 PRKAR 2 PRKAR2 PRKAR2B Protein kinase cAMP dependent regulatory type II beta RATDNA RII beta RII(beta) RIIbeta WUGSC:H RG363E19.2 |
| Molecular Weight(MW) | 46 kDa |
| Cellular Localization | Cell membrane, Cytoplasm, Membrane. |
| SwissProt ID | P31323 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
