| Gene Symbol |
ATP1A1
|
| Gene Synonyms |
CMT2DD HOMGSMR2 |
| Gene Full Name |
ATPase Na+/K+ transporting subunit alpha 1 |
| Gene Summary |
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| Alternative Names |
A1A1 AT1A1 AT1A1_HUMAN ATP1A1 Atpa-1 ATPase Na+/K+ transporting alpha 1 polypeptide ATPase Na+/K+ transporting subunit alpha 1 BC010319 EC 3.6.3.9 MGC3285 MGC38419 MGC51750 Na K ATPase alpha A catalytic polypeptide Na K ATPase catalytic subunit alpha A protein Na(+)/K(+) ATPase 1 Na(+)/K(+) ATPase alpha-1 subunit Na+ K+ ATPase alpha subunit Na+/K+ ATPase alpha 1 subunit Na+/K+ ATPase 1 Na K ATPase alpha 1 subunit Nkaa1b Sodium potassium ATPase alpha 1 polypeptide Sodium pump 1 Sodium pump subunit alpha-1 sodium-potassium ATPase catalytic subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-1 |
| Molecular Weight(MW) |
113 kDa |
| Cellular Localization |
Cell membrane, Basolateral cell membrane, Cell membrane, sarcolemma, Cell projection, axon, Melanosome. |