WB
Western blot analysis of CD206 in mouse liver , rat liver lysates and using CD206 Goat pAb.IF
Immunofluorescence analysis of CD206(Green) in mouse liver tissue using CD206 Goat pAb, and DAPI(Blue)| Product Name | Mannose Receptor/CD206 Goat pAb |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant Human CD206 |
| Modification | Unmodified |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Goat |
| Tested Applications | WBIF |
| WB:1:500-1:1000 IHC:1:100-1:500 IF-P:1:100-1:500 ICC/IF:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity Purified |
| Gene Symbol | MRC1 |
|---|---|
| Gene Synonyms | MMR hMR CD206 MRC1L1 CLEC13D CLEC13DL bA541I19.1 |
| Gene Full Name | mannose receptor C-type 1 |
| Gene Summary | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015] |
| Molecular Weight(MW) | 180-200 kDa(Observed band size: 180-210 kDa) |
| Function | Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778). |
| Cellular Localization | Cell membrane,Endosome,Membrane |
WB
Western blot analysis of CD206 in mouse liver , rat liver lysates and using CD206 Goat pAb.
IF
Immunofluorescence analysis of CD206(Green) in mouse liver tissue using CD206 Goat pAb, and DAPI(Blue)| Application Notes | WB:1:500-1:1000 IHC:1:100-1:500 IF-P:1:100-1:500 ICC/IF:1:100-1:300 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS, 50% glycerol, 0.05% Proclin 300, 0.08%BSA |
