This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome type IV, and with aortic and arterial aneurysms. [provided by R. Dalgleish, Feb 2008]
Molecular Weight(MW)
138 kDa(Observed band size: 150 kDa)
Function
Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. Mutations in th gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
Cellular Localization
Extracellular matrix,Secreted
Application
WB
Western blot analysis of Mouse testis and Rat testis lysates using collagen III Goat pAb
IF
Immunofluorescence analysis of Human testis cancer tissue using collagen III Goat pAb