This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Jun 2022]
Alternative Names
Metastin KiSS-1 Metastasis-Suppressor
Application
IHC
Vector Red staining on IHC-P,Samples: Human Placenta Tissue,Primary Ab: 10µg/ml Mouse Anti-Human KISS1 Antibody Second Ab: 2µg/mL HRP-Linked Caprine Anti-Mouse IgG Monoclonal Antibody
WB
Figure. Western Blot,Sample: Recombinant KISS1, Human.
Application Notes
WB: 0.01-2µg/mL IHC: 5-20µg/mL ICC/IF: 5-20µg/mL
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.