| Product Name | Human PGFRA Recombinant protein |
|---|---|
| Species Reactivity | Human |
| Gene Symbol | PDGFRA |
| Gene Synonyms | CD140A PDGFR2 PDGFR-2 |
| Gene Full Name | platelet derived growth factor receptor alpha |
| Gene Summary | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. |
