The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Alternative Names
Ser/Thr protein kinase tbetaR-II tgf beta receptor 2 TGF-beta receptor II TGF-beta receptor type II TGF-beta receptor type IIB TGF-beta type II receptor TGFbeta RII TGFBR2-SE TGFR-2 TGFR2 transforming growth factor beta receptor II transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_1 transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_2 transforming growth factor beta receptor type II transforming growth factor beta receptor type IIC transforming growth factor beta receptor II transforming growth factor beta receptor II (70/80kDa) transforming growth factor beta receptor II alpha transforming growth factor beta receptor II beta transforming growth factor beta receptor II delta transforming growth factor beta receptor II epsilon transforming growth factor beta receptor II gamma transforming growth factor beta receptor IIT transforming growth factor-b type II receptor transforming growth factor-beta receptor type II transforming growth factor-beta type II receptor type II TGF beta receptor