This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Alternative Names
histone acetyltransferase MYST3 K(lysine) acetyltransferase 6A monocytic leukemia zinc finger homolog monocytic leukemia zinc finger protein MOZ YBF2/SAS3 SAS2 and TIP60 protein 3 MYST histone acetyltransferase (monocytic leukemia) 3 MYST protein 3 MYST-3 runt-related transcription factor binding protein 2 zinc finger protein 220