Western blot
1ug/mlPositive Control: Jurkat cell lysate| Product Name | Rabbit anti-MAP3K8 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT |
| Immunogen | The immunogen for anti-MAP3K8 antibody: synthetic peptide directed towards the C terminal of human MAP3K8 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 |
|
| Species Reactivity | BovineDogHorseHumanMouseRabbitRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | MAP3K8 |
|---|---|
| Gene Synonyms | COT EST ESTF TPL2 MEKK8 Tpl-2 c-COT |
| Gene Full Name | Mitogen-activated protein kinase kinase kinase 8 |
| Gene Summary | MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. |
| Alternative Names | COT EST ESTF TPL2 MEKK8 Tpl-2 c-COT |
| Molecular Weight(MW) | 53kDa |
| Sequence | 467 amino acids |
Western blot
1ug/mlPositive Control: Jurkat cell lysate| Application Notes | WB:1:500~1:2000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
