| Product Name | Anti-Phospho-MAP3K8/COT (Ser443) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Synthetic peptide conjugated with KLH. |
| Modification | p-Ser443 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MAP3K8 |
|---|---|
| Gene Synonyms | COT EST ESTF TPL2 AURA2 MEKK8 Tpl-2 c-COT |
| Gene Full Name | mitogen-activated protein kinase kinase kinase 8 |
| Gene Summary | This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] |
| Alternative Names | AURA2 c COT Cancer Osaka thyroid oncogene CCOT COT COT proto oncogene serine/threonine protein kinase EST ESTF Ewing sarcoma transformant FLJ10486 M3K8_HUMAN MAP3K 8 MAP3K8 MEKK8 Mitogen activated protein kinase kinase kinase 8 Mitogen-activated protein kinase kinase kinase 8 Proto oncogene cCot Proto-oncogene c-Cot Serine/threonine protein kinase cot Serine/threonine-protein kinase cot TPL 2 TPL-2 TPL2 Tumor progression locus 2 |
| Molecular Weight(MW) | 53 kDa |
| Cellular Localization | Cytoplasm. |
| SwissProt ID | P41279 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
