Western blot
AIRE antibody - N-terminal region validated by WB using human LCL at 1:1000.Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Live| Product Name | Rabbit anti-AIRE polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AIRE1, APECED, APS1, APSI, PGA1 |
| Immunogen | The immunogen for anti-AIRE antibody: synthetic peptide directed towards the N terminal of human AIRE |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | AIRE |
|---|---|
| Gene Synonyms | AIRE1 APECED APS1 APSI PGA1 |
| Gene Full Name | Autoimmune regulator |
| Gene Summary | The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). |
| Alternative Names | AIRE1 APECED APS1 APSI PGA1 |
| Molecular Weight(MW) | 58kDa |
| Sequence | 545 amino acids |
Western blot
AIRE antibody - N-terminal region validated by WB using human LCL at 1:1000.
Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Live| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
