Western blot
0.2-1 ug/ml| Product Name | COPS2 antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-COPS2 antibody: synthetic peptide directed towards the N terminal of human COPS2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Species Reactivity | Bovine,Dog,Guinea Pig,Horse,Human,Mouse,Pig,Rabbit,Rat,Zebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | COPS2 |
|---|---|
| Gene Synonyms | ALIEN CSN2 SGN2 TRIP15 |
| Gene Full Name | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) |
| Gene Summary | COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
| Alternative Names | ALIEN CSN2 SGN2 TRIP15 |
| Molecular Weight(MW) | 52kDa |
| Sequence | 443 amino acids |
Western blot
0.2-1 ug/ml| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
