Western blot
Titration: 1.0 ug/ml| Product Name | Eya4 Antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for Anti-Eya4 antibody is: synthetic peptide directed towards the N-terminal region of Eya4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Species Reactivity | Guinea Pig,Human,Mouse,Rabbit,Zebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Eya4 |
|---|---|
| Gene Synonyms | B130023L16Rik |
| Gene Full Name | Eyes absent 4 homolog (Drosophila) |
| Gene Summary | Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye. |
| Alternative Names | B130023L16Rik |
| Molecular Weight(MW) | 67kDa |
| Sequence | 616 amino acids |
Western blot
Titration: 1.0 ug/ml| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
