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Catalog Number: OM110692

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OM110692-100ul

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100ul

OM110692-50ul

50ul

OM110692-20ul

20ul

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Product Profile

Product Name	Rabbit anti-F13B polyclonal antibody - middle region
Antibody Type	Primary Antibodies
Antigen Alias	FXIIIB
Immunogen	The immunogen for anti-F13B antibody: synthetic peptide directed towards the middle region of human F13B

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WB
	WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity	BovineDogGuinea PigHorseHumanMouseRabbitRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Gene Symbol	F13B
Gene Synonyms	F13B
Gene Full Name	Coagulation factor XIII, B polypeptide
Gene Summary	F13B contains 10 Sushi (CCP/SCR) domains. The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alternative Names	FXIIIB
Molecular Weight(MW)	73kDa
Sequence	661 amino acids

Database Links

Entrez Gene	2165
SwissProt ID	P05160
Protein Accession	NP_001985

Application

Application

Rabbit Anti-F13B antibodyCatalog Number: ARP41999Formalin Fixed Paraffin Embedded Tissue: Human VesselPrimary antibody Concentration: 1:100Secondary Antibody: Donkey anti-Rabbit-Cy3Secondary Antibody Concentration: 1:200Magnification: 20xExposure Time: 0.5-2.0sec

Application

Application Notes	WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form	Liquid
Storage Instructions	Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

validation

Data sheet for OM110692

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