Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: MCF7 cell lysate| Product Name | Rabbit anti-CLEC4M polyclonal antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD299, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR, MGC47866, MGC129964, CLEC4M |
| Immunogen | The immunogen for anti-CLEC4M antibody: synthetic peptide directed towards the middle region of human CLEC4M |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CLEC4M |
|---|---|
| Gene Synonyms | CD299 LSIGN CD209L L-SIGN DCSIGNR HP10347 DC-SIGN2 DC-SIGNR MGC47866 MGC129964 CLEC4M |
| Gene Full Name | C-type lectin domain family 4, member M |
| Gene Summary | CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. |
| Alternative Names | CD299 LSIGN CD209L L-SIGN DCSIGNR HP10347 DC-SIGN2 DC-SIGNR MGC47866 MGC129964 CLEC4M |
| Molecular Weight(MW) | 30kDa |
| Sequence | 263 amino acids |
| Entrez Gene | 10332 |
|---|---|
| SwissProt ID | Q9H2X3 |
| Protein Accession | NP_001138378 |
Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: MCF7 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
