Western blot
Host: Rabbit Target Name: Axin1 Sample Tissue: Mouse Testis lysates Antibody Dilution: 1.0ug/ml| Product Name | Rabbit anti-Axin1 Antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly |
| Immunogen | The immunogen for Anti-Axin1 antibody is: synthetic peptide directed towards the N-terminal region of Mouse Axin1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | MouseHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Axin1 |
|---|---|
| Gene Synonyms | AI316800 Axin Fu Kb Ki fused kinky knobbly |
| Gene Summary | Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. |
| Alternative Names | AI316800 Axin Fu Kb Ki fused kinky knobbly |
| Molecular Weight(MW) | 110kDa |
| Sequence | 993 amino acids |
Western blot
Host: Rabbit Target Name: Axin1 Sample Tissue: Mouse Testis lysates Antibody Dilution: 1.0ug/ml| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
