Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human kidney| Product Name | Rabbit anti-CLSTN1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CSTN1, FLJ32258, KIAA0911, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CDHR12, ALC-ALPHA |
| Immunogen | The immunogen for anti-CLSTN1 antibody: synthetic peptide directed towards the N terminal of human CLSTN1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanPigRabbitRatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CLSTN1 |
|---|---|
| Gene Synonyms | CSTN1 FLJ32258 KIAA0911 PIK3CD XB31alpha alcalpha1 alcalpha2 CDHR12 ALC-ALPHA |
| Gene Full Name | Calsyntenin 1 |
| Gene Summary | CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals. |
| Alternative Names | CSTN1 FLJ32258 KIAA0911 PIK3CD XB31alpha alcalpha1 alcalpha2 CDHR12 ALC-ALPHA |
| Molecular Weight(MW) | 110kDa |
| Sequence | 981 amino acids |
| Entrez Gene | 22883 |
|---|---|
| SwissProt ID | O94985 |
| Protein Accession | NP_001009566 |
Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human kidney| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
