Western blot
NRG1 (neuregulin 1) Antibody (against the middle region of NRG1) (50ug) validated by WB using Jurkat cell lysate at 0.2-1 ug/ml.| Product Name | Rabbit anti-NRG1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF, MST131 |
| Immunogen | Synthetic peptide directed towards the middle region of human NRG1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NRG1 |
|---|---|
| Gene Synonyms | ARIA GGF GGF2 HGL HRG HRG1 HRGA NDF SMDF MST131 |
| Gene Full Name | Neuregulin 1 |
| Gene Summary | Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. |
| Alternative Names | ARIA GGF GGF2 HGL HRG HRG1 HRGA NDF SMDF MST131 |
| Molecular Weight(MW) | 32kDa |
| Sequence | 296 amino acids |
Western blot
NRG1 (neuregulin 1) Antibody (against the middle region of NRG1) (50ug) validated by WB using Jurkat cell lysate at 0.2-1 ug/ml.| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
