HAI MT-SP1 MTSP-1 MTSP1 PRSS14 SNC19 TADG-15 TADG15 TMPRSS14
Gene Full Name
Suppression of tumorigenicity 14 (colon carcinoma)
Gene Summary
ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
Alternative Names
HAI MT-SP1 MTSP-1 MTSP1 PRSS14 SNC19 TADG-15 TADG15 TMPRSS14