Western blot
RabbitTarget Name: Senp6Antibody Dilution: 1.0ug/mlSample Tissue: Mouse Lung| Product Name | Rabbit anti-Senp6 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | MouseHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Senp6 |
|---|---|
| Gene Synonyms | 2810017C20Rik E130319N12Rik MGC38009 Susp1 mKIAA0797 |
| Gene Full Name | SUMO/sentrin specific peptidase 6 |
| Gene Summary | Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. |
| Alternative Names | 2810017C20Rik E130319N12Rik MGC38009 Susp1 mKIAA0797 |
| Molecular Weight(MW) | 127kDa |
| Sequence | 1132 amino acids |
Western blot
RabbitTarget Name: Senp6Antibody Dilution: 1.0ug/mlSample Tissue: Mouse Lung| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
