Eid2 interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. It inhibits EP300 ihistone acetyltransferase activity. It acts as a repressor of TGFB/SMAD transcriptional responses. It may act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.