Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Stomach| Product Name | Rabbit anti-FBXO31 polyclonal antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DKFZP434B027, DKFZp434J1815, FBX14, FBXO14, FLJ22477, Fbx31, MGC15419, MGC9527, pp2386 |
| Immunogen | The immunogen for anti-FBXO31 antibody: synthetic peptide directed towards the middle region of human FBXO31 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogHorsePigRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FBXO31 |
|---|---|
| Gene Synonyms | DKFZP434B027 DKFZp434J1815 FBX14 FBXO14 FLJ22477 Fbx31 MGC15419 MGC9527 pp2386 |
| Gene Full Name | F-box protein 31 |
| Gene Summary | FBXO31 is the component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. FBXO31 specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor.Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM]. |
| Alternative Names | DKFZP434B027 DKFZp434J1815 FBX14 FBXO14 FLJ22477 Fbx31 MGC15419 MGC9527 pp2386 |
| Molecular Weight(MW) | 40kDa |
| Sequence | 367 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Stomach| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
