Western blot
Host: Rabbit Target Name: ULK1 Sample Tissue: Thymus Tumor lysates Antibody Dilution: 1.0ug/ml| Product Name | Rabbit anti-ULK1 Antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ATG1, ATG1A, UNC51, Unc51.1, hATG1 |
| Immunogen | The immunogen for Anti-ULK1 antibody is: synthetic peptide directed towards the N-terminal region of Human ULK1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMousePigRabbitRatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ULK1 |
|---|---|
| Gene Synonyms | ATG1 ATG1A UNC51 Unc51.1 hATG1 |
| Gene Full Name | unc-51-like kinase 1 (C. elegans) |
| Gene Summary | ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation. |
| Alternative Names | ATG1 ATG1A UNC51 Unc51.1 hATG1 |
| Molecular Weight(MW) | 112kDa |
| Sequence | 1050 amino acids |
Western blot
Host: Rabbit Target Name: ULK1 Sample Tissue: Thymus Tumor lysates Antibody Dilution: 1.0ug/ml| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
