Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human kidney| Product Name | Rabbit anti-GUCA1A polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COD3, GCAP, GCAP1, GUCA, GUCA1, CORD14, C6orf131, dJ139D8.6 |
| Immunogen | The immunogen for anti-GUCA1A antibody: synthetic peptide directed towards the N terminal of human GUCA1A |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | DogHorseHumanMousePigRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GUCA1A |
|---|---|
| Gene Synonyms | COD3 GCAP GCAP1 GUCA GUCA1 CORD14 C6orf131 dJ139D8.6 |
| Gene Full Name | Guanylate cyclase activator 1A (retina) |
| Gene Summary | GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. |
| Alternative Names | COD3 GCAP GCAP1 GUCA GUCA1 CORD14 C6orf131 dJ139D8.6 |
| Molecular Weight(MW) | 23kDa |
| Sequence | 201 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human kidney| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
