Western blot
0.2-1 ug/mlPositive Control: THP-1 cell lysate| Product Name | Rabbit anti-RIC8A polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC104517, MGC131931, MGC148073, MGC148074, RIC8, synembryn |
| Immunogen | The immunogen for anti-RIC8A antibody: synthetic peptide directed towards the N terminal of human RIC8A |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMouseRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | RIC8A |
|---|---|
| Gene Synonyms | MGC104517 MGC131931 MGC148073 MGC148074 RIC8 synembryn |
| Gene Full Name | Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) |
| Gene Summary | RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
| Alternative Names | MGC104517 MGC131931 MGC148073 MGC148074 RIC8 synembryn |
| Molecular Weight(MW) | 60kDa |
| Sequence | 537 amino acids |
Western blot
0.2-1 ug/mlPositive Control: THP-1 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
