Western blot
Host: Rabbit Target Name: Pcsk1n Sample Tissue: Rat Thymus lysates Antibody Dilution: 1.0ug/ml| Product Name | Rabbit anti-Pcsk1n Antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Saas |
| Immunogen | The immunogen for Anti-Pcsk1n antibody is: synthetic peptide directed towards the N-terminal region of Rat Pcsk1n |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | RatHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Pcsk1n |
|---|---|
| Gene Synonyms | Saas |
| Gene Full Name | proprotein convertase subtilisin/kexin type 1 inhibitor |
| Gene Summary | Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known. |
| Alternative Names | Saas |
| Molecular Weight(MW) | 28kDa |
| Sequence | 260 amino acids |
Western blot
Host: Rabbit Target Name: Pcsk1n Sample Tissue: Rat Thymus lysates Antibody Dilution: 1.0ug/ml| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
