Vamp8 is involved in the targeting and/or fusion of transport vesicles to their target membrane. Vamp8 plays a role in regulated enzyme secretion in pancreatic acinar cells.Vamp8 is involved for dense-granule secretion in platelets. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Vamp8 is involved in the homotypic fusion of early and late endosomes.