Western blot
Titration: 1.0 ug/mlPositive Control: THP-1 Whole Cell| Product Name | Rabbit anti-INPP5D polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMousePigRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | INPP5D |
|---|---|
| Gene Synonyms | MGC104855 MGC142140 MGC142142 SHIP SHIP1 SIP-145 hp51CN |
| Gene Full Name | Inositol polyphosphate-5-phosphatase, 145kDa |
| Gene Summary | This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| Alternative Names | MGC104855 MGC142140 MGC142142 SHIP SHIP1 SIP-145 hp51CN |
| Molecular Weight(MW) | 131kDa |
| Sequence | 1189 amino acids |
| Entrez Gene | 3635 |
|---|---|
| SwissProt ID | Q92835 |
| Protein Accession | NP_001017915 |
Western blot
Titration: 1.0 ug/mlPositive Control: THP-1 Whole Cell| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
