Western blot
Titration: 1.0 ug/mlPositive Control: THP-1 Whole Cell| Product Name | Rabbit anti-BAG4 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BAG-4, SODD |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogHorseHumanPigRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BAG4 |
|---|---|
| Gene Synonyms | BAG-4 SODD |
| Gene Full Name | BCL2-associated athanogene 4 |
| Gene Summary | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| Alternative Names | BAG-4 SODD |
| Molecular Weight(MW) | 46kDa |
| Sequence | 421 amino acids |
| Entrez Gene | 9530 |
|---|---|
| SwissProt ID | B4E217 |
| Protein Accession | NP_001191807 |
Western blot
Titration: 1.0 ug/mlPositive Control: THP-1 Whole Cell| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
