Western blot
Titration: 1.0 ug/mlPositive Control: Fetal Heart| Product Name | Rabbit anti-BRCC3 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BRCC36, C6.1A, CXorf53, RP11-143H17.2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineGuinea PigHorseHumanMousePigRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BRCC3 |
|---|---|
| Gene Synonyms | BRCC36 C6.1A CXorf53 RP11-143H17.2 |
| Gene Full Name | BRCA1/BRCA2-containing complex, subunit 3 |
| Gene Summary | This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. |
| Alternative Names | BRCC36 C6.1A CXorf53 RP11-143H17.2 |
| Molecular Weight(MW) | 35kDa |
| Sequence | 316 amino acids |
Western blot
Titration: 1.0 ug/mlPositive Control: Fetal Heart| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
