DIRA ICIL-1RA IL-1ra3 IL1F3 IL1RA IRAP MGC10430 MVCD4 IL-1RN IL-1ra
Gene Full Name
Interleukin 1 receptor antagonist
Gene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alternative Names
DIRA ICIL-1RA IL-1ra3 IL1F3 IL1RA IRAP MGC10430 MVCD4 IL-1RN IL-1ra