Western blot
Host: Rabbit Target Name: Fgfr1 Sample Tissue: Mouse Liver lysates Antibody Dilution: 1.0ug/ml| Product Name | Rabbit anti-Fgfr1 Antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy |
| Immunogen | The immunogen for Anti-Fgfr1 antibody is: synthetic peptide directed towards the N-terminal region of Mouse Fgfr1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | MouseHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Fgfr1 |
|---|---|
| Gene Synonyms | AW208770 Eask FLG Fgfr-1 Flt-2 Hspy |
| Gene Full Name | fibroblast growth factor receptor 1 |
| Gene Summary | Fgfr1 is a Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Fgfr1 phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. It promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, Fgfr1 enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation |
| Alternative Names | AW208770 Eask FLG Fgfr-1 Flt-2 Hspy |
| Molecular Weight(MW) | 92kDa |
| Sequence | 822 amino acids |
| Entrez Gene | 14182 |
|---|---|
| SwissProt ID | P16092 |
| Protein Accession | NP_034336' target='_blank'>NP_034336 Nucleotide Accession#: |
Western blot
Host: Rabbit Target Name: Fgfr1 Sample Tissue: Mouse Liver lysates Antibody Dilution: 1.0ug/ml| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Data sheet for OM119421